Russ Ferland, Ph.D.
Professor
Chair, Department Biomedical Sciences, COM
Location
我们研究的综合长期目标是更好地了解分子, genetic, and cellular mechanisms causing neurodevelopmental and neurological disorders. Overall, 我的研究兴趣主要集中在大脑发育障碍和神经系统疾病的研究, and specifically involve the following areas of investigation:
1) functional analyses of AHI1 and CSPP1我们在Joubert综合征的个体中定位并克隆了两个新基因(Hsiao et al .)., J. Neurosci., 2021; Munoz and Ferland, J. Cell Sci., 2019; Bourgeois and Ferland, Dev. Biol., 2019; Tuz et al., Am. J. Hum. Genet., 2014; Tuz et al., J. Biol. Chem., 2013; Westfall et al., J. Neurosci., 2010; Hsiao et al., Hum. Mol. Genet., 2009; Doering et al., J. Comp. Neurol., 2008; Ferland et al., Nature Genetics, 2004),
2)初级非运动纤毛在发育和疾病中的形成和功能(Hua and Ferland), Methods Cell Bio., 2023; Hsiao et al., J. Neurosci., 2021; Munoz and Ferland, J. Cell Sci., 2019; Munoz and Ferland, J. Cell Sci., 2019; Bourgeois and Ferland, Dev. Biol., 2019; Hua and Ferland, Bioessays, 2018; Hua and Feland, Cell. Mol. Life Sci., 2018; Hua and Ferland, Cilia, 2017; Tuz et al., Am. J. Hum. Genet., 2014; Tuz et al., J. Biol. Chem., 2013; Hsiao et al., Cilia, 2012; Westfall et al., J. Neurosci., 2010; Hsiao et al., Hum. Mol. Genet., 2009),
3) genetic and neuroanatomical mechanisms of seizure threshold, seizure propagation, epileptogenesis, and Sudden Unexplained Death in Epilepsy (SUDEP) (Wilson, et al., FASEB J., 2021; Ferland et al., G3 Genes, Genom. Genet, 2017; Ferland, 2017; Loscher, Ferland, and Ferraro, Epilepsy and Behavior, 2017; Kadiyala et al., J. Neurosci., 2016; Kadiyala et al., Epil. Res., 2015; Kadiyala et al., PLoS ONE, 2014; Papandrea et al., Exp. Neurol., 2009; Papandrea et al., Epil. Res., 2009; Ferland et al, 1998a,b,c, 1999, 2002a,b, 2003).
Credentials
Education
Post-Doctoral Training
Harvard Medical School & Howard Hughes Medical Institute (Boston, Massachusetts)
Research
Selected publications
Srinivasan A, Srinivasan A, Ferland RJ. AutoSholl allows for automation of Sholl analysis independent of user tracing. J Neurosci Methods, 331:1-6, 2020. Source code & compiled version of the algorithm are available at: http://github.com/ferlandlab/AutoSholl
Hua K and Ferland RJ. 在纤毛病的背景下重新考虑初级纤毛:纤毛蛋白的纤毛和纤毛功能集中在一个极性主题上? Bioessays, 40, 1700132, 1-11, 2018.
- This work was highlighted in F1000Prime, 5 Dec, 2018.
Srinivasan A, Muñoz-Estrada J, Bourgeois JR, Nalwalk J, Pumiglia K, Sheen V, Ferland RJ. BranchAnalysis2D/3D automates morphometry analyses of branching structures. J Neurosci Methods, 294:1-6, 2018. Source code & compiled version of the algorithm are available at: http://github.com/ferlandlab/BranchAnalysis2D-3D
Hsiao Y-C, Tuz K, Ferland RJ, Trafficking in and to the primary cilium. Cilia, 1:4 (1-13), 2012
- This work was highlighted in F1000 Prime, 31 Jul 2008.
Other scholarly activity
Book Chapters:
Löscher W, Ferland RJ, Ferraro TN. Strain effects on expression of seizures and epilepsy. 见:癫痫和癫痫模型,第二版,剑桥:学术出版社(2017)pp. 21-38. ISBN 9780128040669
Hua K, Bourgeois JR, Ferland RJ. Joubert syndrome. 见:参考模块在神经科学和生物行为心理学,爱思唯尔(2017)pp. 1-8. ISBN 9780128093245
Ferland RJ, Walsh CA. 朱伯特综合征的遗传学:对大脑后中线发育的洞察. In: Squire, LR (Ed.) Encyclopedia of Neuroscience. San Diego: Academic Press (2009) pp. 249-256.
Applegate CD, Burchfiel JL, Ferland RJ, Nierenberg J. The role of rhinencephalic networks in the late stages of kindling. In: Corcoran, M and Moshe, S (Eds.) Kindling 5. New York: Raven Press (1998) pp. 151-165.
Invited Editorials:
Ferland RJ and Guerrini R. Nodular heterotopia is built upon layers. Neurology, 73: 742-743, 2009.
Ferland R and Hua K. Referee Report For: Murine Cep290 phenotypes are modified by genetic backgrounds and provide an impetus for investigating disease modifier alleles [version 1; referees: 2 approved] F1000Research 2015, 4:590 (doi: 10.5256/f1000research.7495.r10185)
Hua K and Ferland RJ. 初级纤毛:发信号的毛发状细胞器的故事变得更加复杂. Atlas of science, 2019. http://atlasofscience.org/primary-cilia-the-story-of-the-hair-like-organelle-that-signals-just-became-more-complicated/